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Target
Bcl-2-like protein 1
Ligand
BDBM50480872
Substrate
n/a
Meas. Tech.
ChEMBL_589117 (CHEMBL1038470)
Kd
0.0314±n/a nM
Citation
 Di Micco, S; Vitale, R; Pellecchia, M; Rega, MF; Riva, R; Basso, A; Bifulco, G Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach. J Med Chem 52:7856-67 (2009) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50480872
Synonyms:
CHEMBL582896
Type:
Small organic molecule
Emp. Form.:
C35H37N3O3
Mol. Mass.:
547.6866
SMILES:
OC[C@@H]1C=C[C@@H](NCc2ccccc2)[C@@H](O)[C@H]1N(Cc1ccccc1)[C@@H](C(=O)Nc1ccccc1)c1ccccc1 |r,c:3|
Structure:
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