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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM50481097
Substrate
n/a
Meas. Tech.
ChEMBL_597843 (CHEMBL1039106)
IC50
14±n/a nM
Citation
 Ramnauth, J; Surman, MD; Sampson, PB; Forrest, B; Wilson, J; Freeman, E; Manning, DD; Martin, F; Toro, A; Domagala, M; Awrey, DE; Bardouniotis, E; Kaplan, N; Berman, J; Pauls, HW 2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI. Bioorg Med Chem Lett 19:5359-62 (2009) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:
Enzyme
Mol. Mass.:
27861.12
Organism:
Escherichia coli
Description:
n/a
Residue:
262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK
  
Inhibitor
Name:
BDBM50481097
Synonyms:
CHEMBL565647
Type:
Small organic molecule
Emp. Form.:
C22H24N4O2
Mol. Mass.:
376.4516
SMILES:
CN(Cc1oc2ccccc2c1C)C(=O)\C=C\c1cnc2NCCNCc2c1
Structure:
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