Reaction Details Report a problem with these data
Target
Protein Tat
Ligand
BDBM50481921
Substrate
n/a
Meas. Tech.
ChEMBL_622389 (CHEMBL1100196)
IC50
30000±n/a nM
Citation
 Wang, D; Iera, J; Baker, H; Hogan, P; Ptak, R; Yang, L; Hartman, T; Buckheit, RW; Desjardins, A; Yang, A; Legault, P; Yedavalli, V; Jeang, KT; Appella, DH Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication. Bioorg Med Chem Lett 19:6893-7 (2009) [PubMed]  Article 
Target
Name:
Protein Tat
Synonyms:
Human immunodeficiency virus type 1 Tat protein | TAT_HV1H2 | tat
Type:
PROTEIN
Mol. Mass.:
9851.32
Organism:
Human immunodeficiency virus type 1 (isolate HXB2 group M subtype B)(HIV-1)
Description:
ChEMBL_320712
Residue:
86
Sequence:
MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE
  
Inhibitor
Name:
BDBM50481921
Synonyms:
CHEMBL1075829
Type:
Small organic molecule
Emp. Form.:
C48H63N7O6
Mol. Mass.:
834.0571
SMILES:
N[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CNCCC(N)=O)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1 |r|
Structure:
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