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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50482064
Substrate
n/a
Meas. Tech.
ChEMBL_627582 (CHEMBL1113588)
IC50
1020±n/a nM
Citation
 Cheng, K; Zheng, QZ; Hou, J; Zhou, Y; Liu, CH; Zhao, J; Zhu, HL Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. Bioorg Med Chem 18:2447-55 (2010) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50482064
Synonyms:
CHEMBL1090240
Type:
Small organic molecule
Emp. Form.:
C18H19IN2O3
Mol. Mass.:
438.2595
SMILES:
CC(CNC(=O)c1ccc(C)cc1O)\N=C\c1cc(I)ccc1O
Structure:
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