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Target
Histone-lysine N-methyltransferase PR-Set7
Ligand
BDBM50315537
Substrate
n/a
Meas. Tech.
ChEMBL_650290 (CHEMBL1224948)
IC50
>180000±n/a nM
Citation
 Greiner, D; Bonaldi, T; Eskeland, R; Roemer, E; Imhof, A Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1:143-5 (2005) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase PR-Set7
Synonyms:
Lysine N-methyltransferase 5A | PR/SET domain-containing protein 07 | dSET8 | KMT5A_DROME | PR-Set7 | KMT5A
Type:
PROTEIN
Mol. Mass.:
76499.49
Organism:
Fruit fly
Description:
ChEMBL_861236
Residue:
691
Sequence:
MIMVRRRQRPAKEAASSSSGGASSGSGIPVDQALPLNVAGNLLEDQYFASPKRKDCRLMKVTQNGQLPEATMMAHNKDNKAGRTIGVPLATRSQTRTIENFFKANAAAKDSQKTIHTEEQLNLGNQELKLDDEELNGQIKLDDEVLKLADKQINENLPFADEVDAKAEQKLMDEELQQVVEELLFDGSSRASSNSPFYQHDMDVMQEIQQTPEIPHIKKVTEPLEGLGSLADFQTHRSALRDSHSSTHSSSTDNIFLQEPVLTLDIDRTPTKASSIKINRSFELAGAVFSSPPSVLNACLNGRFNQIVSLNGQKEALDLPHFDLDQHDSSSCDSGVACGLTANTESPAGQPRRRKPATPHRILCPSPIKTALKVTGGICKVGSADPLSPRKSPRKLPTTTAAVAACKSRRRLNQPKPQAPYQPQLQKPPSQQQQQQQDDIVVVLDDDDDEGDDEDDVRALIKAAEERENQNKAPATANSNKAGMKTMLKPAPVKSKTKSKGPTKGQPPLPLAATNGNREMTDFFPVRRSVRKTKTAVKEEWMRGLEQAVLEERCDGLQVRHFMGKGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCIDATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDYGDRSKESLLHHPWLAF
  
Inhibitor
Name:
BDBM50315537
Synonyms:
chaetocin | CHEMBL1089316
Type:
Small organic molecule
Emp. Form.:
C30 H28 N6 O6 S4
Mol. Mass.:
696.83992
SMILES:
CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21 |r,THB:36:35:31.33:26.27,7:15:1.2:22.21,38:37:31.33:26.27,17:16:1.2:22.21|
Structure:
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