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Target
Penicillin-binding protein 2x
Ligand
BDBM50482776
Substrate
n/a
Meas. Tech.
ChEMBL_672076 (CHEMBL1267457)
IC50
1460±n/a nM
Citation
 Kosowska-Shick, K; McGhee, PL; Appelbaum, PC Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob Agents Chemother 54:1670-7 (2010) [PubMed]  Article 
Target
Name:
Penicillin-binding protein 2x
Synonyms:
PBPX_STRPN | pbpX
Type:
PROTEIN
Mol. Mass.:
82307.00
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_653273
Residue:
750
Sequence:
MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNFAVIIGTGTRFGTDLAKEAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDENYKSATGKILYVEKTQFNKVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITYANMMSIKKELEAAEVKGIDFTTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSGMESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQMDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITEDFVWRDILYQSNYEPGSTMKVMMLAAAIDNNTFPGGEVFNSSELKIADATIRDWDVNEGLTGGRTMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLNRFKFGVPTRFGLTDEYAGQLPADNIVNIAQSSFGQGISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARKSQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQIADEKNGGYLVGLTDYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQLGEFANPILERASAMKDSLNLQTTAKALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQPIVVGTGTKIKNSSAEEGKNLAPNQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEFQGSGSTVQKQDVRANTAIKDIKKITLTLGD
  
Inhibitor
Name:
BDBM50482776
Synonyms:
CHEBI:70718 | Ceftaroline Fosamil | PPI-0903 | TAK-599
Type:
Small organic molecule
Emp. Form.:
C22H21N8O8PS4
Mol. Mass.:
684.685
SMILES:
[H][C@]12SCC(Sc3nc(cs3)-c3cc[n+](C)cc3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC)\c1nsc(NP(O)(O)=O)n1)C([O-])=O |r,c:19|
Structure:
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