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Target
Penicillin-binding protein 2B
Ligand
BDBM50422689
Substrate
n/a
Meas. Tech.
ChEMBL_706040 (CHEMBL1662854)
IC50
54.2±n/a nM
Citation
 Kosowska-Shick, K; McGhee, P; Appelbaum, PC Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. Antimicrob Agents Chemother 53:2176-80 (2009) [PubMed]  Article 
Target
Name:
Penicillin-binding protein 2B
Synonyms:
PBP2_STRPN | Penicillin-binding protein 2B | pbp2b | pbp2b | penA
Type:
PROTEIN
Mol. Mass.:
73859.38
Organism:
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Description:
ChEMBL_103544
Residue:
680
Sequence:
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN
  
Inhibitor
Name:
BDBM50422689
Synonyms:
640/359 | CEFUROXIME
Type:
Small organic molecule
Emp. Form.:
C16H16N4O8S
Mol. Mass.:
424.385
SMILES:
CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(COC(N)=O)=C(N2C1=O)C(O)=O)c1ccco1 |r,c:16|
Structure:
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