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Target
Penicillin-binding protein 1A
Ligand
BDBM50483324
Substrate
n/a
Meas. Tech.
ChEMBL_706008 (CHEMBL1662822)
IC50
52.6±n/a nM
Citation
 Kosowska-Shick, K; McGhee, P; Appelbaum, PC Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. Antimicrob Agents Chemother 53:2176-80 (2009) [PubMed]  Article 
Target
Name:
Penicillin-binding protein 1A
Synonyms:
2.4.1.129 | 3.4.16.4 | DD-transpeptidase | PBP-1A | PBPA_STRPN | Penicillin-binding protein 1A | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Peptidoglycan TGase | ponA
Type:
PROTEIN
Mol. Mass.:
79749.99
Organism:
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Description:
ChEMBL_103552
Residue:
719
Sequence:
MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQGYISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQAVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYFGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLTYGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWNSPAPQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
  
Inhibitor
Name:
BDBM50483324
Synonyms:
CHEBI:51257 | Faropenem
Type:
Small organic molecule
Emp. Form.:
C12H15NO5S
Mol. Mass.:
285.316
SMILES:
[H][C@]12SC(=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O)[C@@]1([H])CCCO1 |c:3|
Structure:
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