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Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50483392
Substrate
n/a
Meas. Tech.
ChEMBL_716864 (CHEMBL1670843)
IC50
4.0±n/a nM
Citation
 Mansoor, UF; Vitharana, D; Reddy, PA; Daubaras, DL; McNicholas, P; Orth, P; Black, T; Siddiqui, MA Design and synthesis of potent Gram-negative specific LpxC inhibitors. Bioorg Med Chem Lett 21:1155-61 (2011) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
  
Inhibitor
Name:
BDBM50483392
Synonyms:
CHEMBL1668450
Type:
Small organic molecule
Emp. Form.:
C23H26N4O5
Mol. Mass.:
438.4763
SMILES:
C[C@@H](O)[C@@H](NC(=O)N1CCN(CC1)c1ccc(cc1)C#Cc1ccc(O)cc1)C(=O)NO |r|
Structure:
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