Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50483611
Substrate
n/a
Meas. Tech.
ChEMBL_740786 (CHEMBL1763887)
IC50
>111000±n/a nM
Citation
 Tang, J; Maddali, K; Dreis, CD; Sham, YY; Vince, R; Pommier, Y; Wang, Z 6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase. Bioorg Med Chem Lett 21:2400-2 (2011) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50483611
Synonyms:
CHEMBL1761476
Type:
Small organic molecule
Emp. Form.:
C24H25FN2O5
Mol. Mass.:
440.4641
SMILES:
CCc1c(C(=O)c2cc(C)cc(C)c2)n(COCCc2ccc(F)cc2)c(=O)n(O)c1=O
Structure:
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