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Target
3-oxoacyl-[acyl-carrier-protein] synthase 2
Ligand
BDBM50483832
Substrate
n/a
Meas. Tech.
ChEMBL_745353 (CHEMBL1775473)
IC50
33700±n/a nM
Citation
 Zhang, C; Ondeyka, J; Herath, K; Jayasuriya, H; Guan, Z; Zink, DL; Dietrich, L; Burgess, B; Ha, SN; Wang, J; Singh, SB Platensimycin and platencin congeners from Streptomyces platensis. J Nat Prod 74:329-40 (2011) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 2
Synonyms:
2.3.1.179 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 3-oxoacyl-[acyl-carrier-protein] synthase II | Beta-ketoacyl-ACP synthase II | FABF_STAAU | KAS II | fabF
Type:
PROTEIN
Mol. Mass.:
42419.21
Organism:
Staphylococcus aureus
Description:
ChEMBL_100958
Residue:
403
Sequence:
VITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKIAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFK
  
Inhibitor
Name:
BDBM50483832
Synonyms:
CHEMBL1773150
Type:
Small organic molecule
Emp. Form.:
C24H27NO9
Mol. Mass.:
473.4725
SMILES:
[H][C@]12CC3C[C@@]4(C=C(O)C(=O)[C@@](C)(CCC(=O)Nc5c(O)ccc(C(O)=O)c5O)C14)C(O)[C@@]3(C)O2 |r,t:6,TLB:11:29:34:3.2,4:5:34:3.2,4:3:34:29.5.30,31:30:34:3.2,THB:2:3:29.1.34:30|
Structure:
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