Reaction Details Report a problem with these data
Target
Reverse transcriptase
Ligand
BDBM50484283
Substrate
n/a
Meas. Tech.
ChEMBL_768443 (CHEMBL1832162)
IC50
6800±n/a nM
Citation
 Barral, K; Weck, C; Payrot, N; Roux, L; Durafour, C; Zoulim, F; Neyts, J; Balzarini, J; Canard, B; Priet, S; Alvarez, K Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication. Eur J Med Chem 46:4281-8 (2011) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50484283
Synonyms:
CHEMBL1830070
Type:
Small organic molecule
Emp. Form.:
C8H10N5Na4O9P3S
Mol. Mass.:
537.138
SMILES:
[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[#7]-c1ncnc2n(-[#6]-[#6]-[#8]-[#6]P([#16-])(=O)[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O)cnc12
Structure:
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