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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50484231
Substrate
n/a
Meas. Tech.
ChEMBL_800394 (CHEMBL1948325)
IC50
20±n/a nM
Citation
 Wenglowsky, S; Ren, L; Ahrendt, KA; Laird, ER; Aliagas, I; Alicke, B; Buckmelter, AJ; Choo, EF; Dinkel, V; Feng, B; Gloor, SL; Gould, SE; Gross, S; Gunzner-Toste, J; Hansen, JD; Hatzivassiliou, G; Liu, B; Malesky, K; Mathieu, S; Newhouse, B; Raddatz, NJ; Ran, Y; Rana, S; Randolph, N; Risom, T; Rudolph, J; Savage, S; Selby, LT; Shrag, M; Song, K; Sturgis, HL; Voegtli, WC; Wen, Z; Willis, BS; Woessner, RD; Wu, WI; Young, WB; Grina, J Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors. ACS Med Chem Lett 2:342-7 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50484231
Synonyms:
CHEMBL1822068
Type:
Small organic molecule
Emp. Form.:
C17H17ClFN5O4S
Mol. Mass.:
441.864
SMILES:
CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F
Structure:
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