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Target
Presenilin-1
Ligand
BDBM50484998
Substrate
n/a
Meas. Tech.
ChEMBL_814407 (CHEMBL2019731)
IC50
30±n/a nM
Citation
 Close, J; Heidebrecht, R; Hendrix, J; Li, C; Munoz, B; Surdi, L; Kattar, S; Tempest, P; Moses, P; Geng, X; Hughes, B; Smotrov, N; Moxham, C; Chapnick, J; Kariv, I; Nikov, G; Burke, JE; Deshmukh, S; Jeliazkova-Mecheva, V; Leach, JK; Diaz, D; Xu, L; Yang, Z; Kwei, G; Moy, L; Shah, S; Tanga, F; Kenefic, C; Savage, D; Shearman, M; Ball, RG; McNevin, MJ; Markarewicz, A; Miller, T Lead optimization of 4,4-biaryl piperidine amides as ?-secretase inhibitors. Bioorg Med Chem Lett 22:3203-7 (2012) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50484998
Synonyms:
CHEMBL2019013
Type:
Small organic molecule
Emp. Form.:
C22H19ClF5NO3S
Mol. Mass.:
507.901
SMILES:
Fc1ccc(F)c(c1)C1(CCN(CC1)C(=O)C1(CC1)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1
Structure:
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