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Target
Reverse transcriptase
Ligand
BDBM2337
Substrate
n/a
Meas. Tech.
ChEMBL_823533 (CHEMBL2045976)
IC50
150±n/a nM
Citation
 Wang, X; Zhang, J; Huang, Y; Wang, R; Zhang, L; Qiao, K; Li, L; Liu, C; Ouyang, Y; Xu, W; Zhang, Z; Zhang, L; Shao, Y; Jiang, S; Ma, L; Liu, J Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile. J Med Chem 55:2242-50 (2012) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM2337
Synonyms:
6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | CHEMBL35033 | Coactinon | Emivirine | Emivirine (EMV) | HEPT deriv. | I-EBU | MKC-442
Type:
Small organic molecule
Emp. Form.:
C17H22N2O3
Mol. Mass.:
302.3682
SMILES:
CCOCn1c(Cc2ccccc2)c(C(C)C)c(=O)[nH]c1=O
Structure:
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