Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 6
Ligand
BDBM50485549
Substrate
n/a
Meas. Tech.
ChEMBL_838470 (CHEMBL2076041)
IC50
1100000±n/a nM
Citation
 Cihlar, T; Ho, ES Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem 283:49-55 (2000) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 6
Synonyms:
OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | S22A6_HUMAN | SLC22A6 | hOAT1 | hPAHT | hROAT1
Type:
PROTEIN
Mol. Mass.:
61831.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1487359
Residue:
563
Sequence:
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
  
Inhibitor
Name:
BDBM50485549
Synonyms:
Cyclic Cidofovir | Cyclic(S)-HPMPC
Type:
Small organic molecule
Emp. Form.:
C8H12N3O5P
Mol. Mass.:
261.1717
SMILES:
Nc1ccn(C[C@H]2COP(O)(=O)CO2)c(=O)n1 |r|
Structure:
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