Reaction Details Report a problem with these data
Target
Adenosine deaminase
Ligand
BDBM50029129
Substrate
n/a
Meas. Tech.
ChEMBL_30809 (CHEMBL645084)
pH
7±n/a
Ki
38000±n/a nM
Comments
extracted
Citation
 Grant, AJ; Lerner, LM Heat-induced formation of alpha,beta-unsaturated nucleoside dialdehydes and their activity with adenosine deaminase. J Med Chem 23:795-8 (1980) [PubMed]  Article 
Target
Name:
Adenosine deaminase
Synonyms:
ADA | ADA_BOVIN | Adenosine aminohydrolase
Type:
Enzyme
Mol. Mass.:
40910.44
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
363
Sequence:
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEFLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAIDLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYHTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFKSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAEQCL
  
Inhibitor
Name:
BDBM50029129
Synonyms:
(2R)-2-[(1S)-1-(6-amino-9H-purin-9-yl)-2-oxoethoxy]-3-hydroxybutanal | CHEMBL168001
Type:
Small organic molecule
Emp. Form.:
C11H13N5O4
Mol. Mass.:
279.252
SMILES:
CC(O)[C@@H](O[C@@H](C=O)n1cnc2c(N)ncnc12)C=O
Structure:
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