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Target
Squalene synthase
Ligand
BDBM50029182
Substrate
n/a
Meas. Tech.
ChEMBL_202111 (CHEMBL808969)
IC50
1400±n/a nM
Citation
 Brown, GR; Butlin, RJ; Chapman, S; Eakin, MA; Foubister, AJ; Freeman, S; Griffiths, D; Harrison, PJ; Johnson, MC; Mallion, KB Phenoxypropylamines: a new series of squalene synthase inhibitors. J Med Chem 38:4157-60 (1995) [PubMed]  Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50029182
Synonyms:
4-(2-Hydroxy-3-isopropylamino-propoxy)-benzoic acid ethyl ester | CHEMBL31608
Type:
Small organic molecule
Emp. Form.:
C15H23NO4
Mol. Mass.:
281.3474
SMILES:
CCOC(=O)c1ccc(OCC(O)CNC(C)C)cc1
Structure:
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