Reaction Details Report a problem with these data
Target
Uracil phosphoribosyltransferase
Ligand
BDBM50340677
Substrate
n/a
Meas. Tech.
ChEMBL_901992 (CHEMBL3050992)
Ki
13000±n/a nM
Citation
  TBA Med Chem Res 21:1149-1155 (2012)    Article 
Target
Name:
Uracil phosphoribosyltransferase
Synonyms:
2.4.2.9 | UMP pyrophosphorylase | UPP_ECOLI | UPRTase | Uracil phosphoribosyltransferase | upp | uraP | uraP
Type:
PROTEIN
Mol. Mass.:
22528.97
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_105518
Residue:
208
Sequence:
MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
  
Inhibitor
Name:
BDBM50340677
Synonyms:
(5-fluorouracil)5-Fluoro-1H-pyrimidine-2,4-dione | 5 fluorouracil | 5-FU | 5-Florouracil | 5-Fluoro-1H-pyrimidine-2,4-dione | 5-Fluoro-1H-pyrimidine-2,4-dione (5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione (5-Fluorouracil) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-FUra) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluoro uracil) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluorouracil)(5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione(5FU) | 5-Fluorouracil | 5-fluoro-uracil | 5-fluoropyrimidine-2,4(1H,3H)-dione | 5-fluorouacil | 5-fluorourasil | 5F-uracil | Adrucil | CHEMBL185 | Carac | Efudex | FLUOROURACIL, 5- | Fluoroplex | Fluracil | Ro-2-9757
Type:
Small organic molecule
Emp. Form.:
C4H3FN2O2
Mol. Mass.:
130.0772
SMILES:
Fc1c[nH]c(=O)[nH]c1=O
Structure:
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