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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50321673
Substrate
n/a
Meas. Tech.
ChEMBL_900691 (CHEMBL3050300)
IC50
38904514±n/a nM
Citation
  TBA Med Chem Res 21:1912-1920 (2012)    Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50321673
Synonyms:
4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)aniline | CHEMBL1169927
Type:
Small organic molecule
Emp. Form.:
C15H12N6
Mol. Mass.:
276.296
SMILES:
Nc1ccc(cc1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Structure:
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