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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50321660
Substrate
n/a
Meas. Tech.
ChEMBL_900691 (CHEMBL3050300)
IC50
4786301±n/a nM
Citation
  TBA Med Chem Res 21:1912-1920 (2012)    Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50321660
Synonyms:
6-(1-benzyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a]pyrazine | CHEMBL1170532
Type:
Small organic molecule
Emp. Form.:
C22H17N5
Mol. Mass.:
351.4039
SMILES:
C(c1ccccc1)n1cc(cn1)-c1cn2c(cnc2cn1)-c1ccccc1
Structure:
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