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Target
Type-2 angiotensin II receptor
Ligand
BDBM50030748
Substrate
n/a
Meas. Tech.
ChEMBL_35282 (CHEMBL647846)
IC50
549±n/a nM
Citation
Edmunds, JJ; Klutchko, S; Hamby, JM; Bunker, AM; Connolly, CJ; Winters, RT; Quin, J; Sircar, I; Hodges, JC; Panek, RL Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists. J Med Chem 38:3759-71 (1995) [PubMed] Article
More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
Inhibitor
Name:
BDBM50030748
Synonyms:
1-(4-{2-Butyl-5-[1-butyl-3-(2-methyl-thiazol-4-ylmethyl)-2,5-dioxo-imidazolidin-(4Z)-ylidenemethyl]-imidazol-1-ylmethyl}-phenyl)-cyclopentanecarboxylic acid | CHEMBL339544
Type:
Small organic molecule
Emp. Form.:
C33H41N5O4S
Mol. Mass.:
603.775
SMILES:
CCCCN1C(=O)N(Cc2csc(C)n2)\C(=C/c2cnc(CCCC)n2Cc2ccc(cc2)C2(CCCC2)C(O)=O)C1=O