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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50031061
Substrate
n/a
Meas. Tech.
ChEMBL_123919 (CHEMBL729453)
IC50
2180±n/a nM
Citation
 Kneubühler, S; Thull, U; Altomare, C; Carta, V; Gaillard, P; Carrupt, PA; Carotti, A; Testa, B Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs. J Med Chem 38:3874-83 (1995) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM50031061
Synonyms:
3-(naphthalen-2-yl)-5H-indeno[1,2-c]pyridazin-5-one | 3-Naphthalen-2-yl-indeno[1,2-c]pyridazin-5-one | CHEMBL127982
Type:
Small organic molecule
Emp. Form.:
C21H12N2O
Mol. Mass.:
308.3328
SMILES:
O=C1c2ccccc2-c2nnc(cc12)-c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: