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Target
Nonstructural protein 5A
Ligand
BDBM50537588
Substrate
n/a
Meas. Tech.
ChEMBL_1969964 (CHEMBL4602782)
IC50
17±n/a nM
Citation
 Ganta, NM; Gedda, G; Rathnakar, B; Satyanarayana, M; Yamajala, B; Ahsan, MJ; Jadav, SS; Balaraju, T A review on HCV inhibitors: Significance of non-structural polyproteins. Eur J Med Chem 164:576-601 (2019) [PubMed]  Article 
Target
Name:
Nonstructural protein 5A
Synonyms:
NS5A | Nonstructural protein 5A
Type:
PROTEIN
Mol. Mass.:
48587.20
Organism:
Hepatitis C virus
Description:
ChEMBL_108438
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRIPGVPFLSCQRGYKGVWRGDGIMHTTCPCGAQITGHVKNGSMRIVGPKTCSNTWHGTFPINTYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFMVGLNQYLVGSQLPCEPEPDVTVLTSMLTDPSHITAETAGRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLQAEEDEREVSVPAEILRKSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSGSSAVDSGTATAPPDQLPGDGDSGSDVESYSSMPPLEGEPGDPDLSDGSWSTMSEEASEDVVCC
  
Inhibitor
Name:
BDBM50537588
Synonyms:
CHEMBL4643189
Type:
Small organic molecule
Emp. Form.:
C37H33ClFN3O4
Mol. Mass.:
638.127
SMILES:
OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccc(cc2-c2ccc(Cl)cc2)N2CCCC2=O)cc1F
Structure:
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