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Target
Alpha-2B adrenergic receptor
Ligand
BDBM50031301
Substrate
n/a
Meas. Tech.
ChEMBL_33501 (CHEMBL647000)
Ki
152±n/a nM
Citation
 Cordi, AA; Lacoste, JM; Descombes, JJ; Courchay, C; Vanhoutte, PM; Laubie, M; Verbeuren, TJ Design, synthesis, and structure-activity relationships of a new series of alpha-adrenergic agonists: spiro[(1,3-diazacyclopent-1-ene)-5,2'-(1',2',3',4'- tetrahydronaphthalene)]. J Med Chem 38:4056-69 (1995) [PubMed]  Article 
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_RAT | Adra2b | Adrenergic receptor alpha | Adrenergic receptor alpha-2 | Alpha-2B adrenergic receptor | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | adrenergic Alpha2B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50379.83
Organism:
NEONATAL RAT
Description:
adrenergic Alpha2B ADRA2B NEONATAL RAT::P19328
Residue:
453
Sequence:
MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
  
Inhibitor
Name:
BDBM50031301
Synonyms:
8'-fluorospiro[4,5-dihydro-1H-imidazole-4,2'-(1',2',3',4'-tetrahydronaphthalene)] | CHEMBL131220
Type:
Small organic molecule
Emp. Form.:
C12H13FN2
Mol. Mass.:
204.2434
SMILES:
Fc1cccc2CCC3(CNC=N3)Cc12 |c:11|
Structure:
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