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Target
Sepiapterin reductase
Ligand
BDBM50537632
Substrate
n/a
Meas. Tech.
ChEMBL_1970294 (CHEMBL4603112)
IC50
6166±n/a nM
Citation
 Gao, H; Schneider, S; Andrews, P; Wang, K; Huang, X; Sparling, BA Virtual screening to identify potent sepiapterin reductase inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM50537632
Synonyms:
CHEMBL4594142
Type:
Small organic molecule
Emp. Form.:
C22H20O7
Mol. Mass.:
396.39
SMILES:
CC1(C)Oc2c(CCO)c3occ(-c4ccc(O)c(O)c4)c(=O)c3c(O)c2C=C1 |c:30|
Structure:
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