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Target
Sepiapterin reductase
Ligand
BDBM50537654
Substrate
n/a
Meas. Tech.
ChEMBL_1970294 (CHEMBL4603112)
IC50
>19000±n/a nM
Citation
 Gao, H; Schneider, S; Andrews, P; Wang, K; Huang, X; Sparling, BA Virtual screening to identify potent sepiapterin reductase inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM50537654
Synonyms:
CHEMBL4643587
Type:
Small organic molecule
Emp. Form.:
C22H19N3O3
Mol. Mass.:
373.4046
SMILES:
COc1ccc(O)c(c1)C(=O)c1cnc2n(nc(C)c2c1)-c1cccc(C)c1
Structure:
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