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Target
Seed linoleate 13S-lipoxygenase-1
Ligand
BDBM50339185
Substrate
n/a
Meas. Tech.
ChEMBL_912922 (CHEMBL3057085)
IC50
220000±n/a nM
Citation
  TBA Med Chem Res 21:2280-2291 (2012)    Article 
Target
Name:
Seed linoleate 13S-lipoxygenase-1
Synonyms:
15-LOX | 15-Lipo-oxygenase (15-LO) | 15-lipo-oxygenase (SLO) | Arachidonic Acid 15- Lipoxygenase | L-1 | LOX1 | LOX1.1 | LOX1_SOYBN | Lipoxygenase (LOX) | Lipoxygenase (SLO) | Lipoxygenase-1 | Seed lipoxygenase-1
Type:
Enzyme
Mol. Mass.:
94365.66
Organism:
Glycine max (soybean)
Description:
n/a
Residue:
839
Sequence:
MFSAGHKIKGTVVLMPKNELEVNPDGSAVDNLNAFLGRSVSLQLISATKADAHGKGKVGKDTFLEGINTSLPTLGAGESAFNIHFEWDGSMGIPGAFYIKNYMQVEFFLKSLTLEAISNQGTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAPLVSYREEELKSLRGNGTGERKEYDRIYDYDVYNDLGNPDKSEKLARPVLGGSSTFPYPRRGRTGRGPTVTDPNTEKQGEVFYVPRDENLGHLKSKDALEIGTKSLSQIVQPAFESAFDLKSTPIEFHSFQDVHDLYEGGIKLPRDVISTIIPLPVIKELYRTDGQHILKFPQPHVVQVSQSAWMTDEEFAREMIAGVNPCVIRGLEEFPPKSNLDPAIYGDQSSKITADSLDLDGYTMDEALGSRRLFMLDYHDIFMPYVRQINQLNSAKTYATRTILFLREDGTLKPVAIELSLPHSAGDLSAAVSQVVLPAKEGVESTIWLLAKAYVIVNDSCYHQLMSHWLNTHAAMEPFVIATHRHLSVLHPIYKLLTPHYRNNMNINALARQSLINANGIIETTFLPSKYSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSTPHGVRLLIEDYPYAADGLEIWAAIKTWVQEYVPLYYARDDDVKNDSELQHWWKEAVEKGHGDLKDKPWWPKLQTLEDLVEVCLIIIWIASALHAAVNFGQYPYGGLIMNRPTASRRLLPEKGTPEYEEMINNHEKAYLRTITSKLPTLISLSVIEILSTHASDEVYLGQRDNPHWTSDSKALQAFQKFGNKLKEIEEKLVRRNNDPSLQGNRLGPVQLPYTLLYPSSEEGLTFRGIPNSISI
  
Inhibitor
Name:
BDBM50339185
Synonyms:
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | (S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid | (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | (S)-naproxen | 2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(6-Methoxy-naphthalen-2-yl)-propionic acid(naproxen) | 2-(6-methoxy-2-naphthyl)propanoic acid | 2-(6-methoxynaphthalen-2-yl)propanoic acid | Aleve | Anaprox | CHEMBL154 | Ec-naprosyn | Equiproxen | Naprelan | Naprosyn | Naproxen | Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid | RS-3540 | S-NAPROXEN | US11459295, Compound S-Naproxen (1) | naproxene
Type:
Small organic molecule
Emp. Form.:
C14H14O3
Mol. Mass.:
230.2592
SMILES:
COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: