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Target
Deoxyhypusine synthase
Ligand
BDBM50009367
Substrate
n/a
Meas. Tech.
ChEMBL_53735 (CHEMBL663660)
IC50
41000±n/a nM
Citation
 Lee, YB; Park, MH; Folk, JE Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity. J Med Chem 38:3053-61 (1995) [PubMed]  Article 
Target
Name:
Deoxyhypusine synthase
Synonyms:
DHYS_RAT | Dhps
Type:
PROTEIN
Mol. Mass.:
40696.63
Organism:
Rattus norvegicus
Description:
ChEMBL_53735
Residue:
369
Sequence:
MEGTPSGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAYGTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHEDLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVQEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED
  
Inhibitor
Name:
BDBM50009367
Synonyms:
1,7-diamino-4-azaheptane | 3,3'-azanediyldi(propanamine) | 3,3'-iminobis(propylamine) | 3,3'-iminodi(propylamine) | 3,3-diaminodipropylamine | 4-azaheptane-1,7-diamine | CHEMBL28743 | N-(3-aminopropyl)-1,3-propanediamine | N-(3-aminopropyl)propane-1,3-diamine | N-3-aminopropyl-1,3-diaminopropane | bis(3-aminopropyl)amine | dipropylenetriamine | norspermidine
Type:
Small organic molecule
Emp. Form.:
C6H17N3
Mol. Mass.:
131.2193
SMILES:
NCCCNCCCN
Structure:
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