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Target
Deoxyhypusine synthase
Ligand
BDBM50032502
Substrate
n/a
Meas. Tech.
ChEMBL_53735 (CHEMBL663660)
IC50
74000±n/a nM
Citation
 Lee, YB; Park, MH; Folk, JE Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity. J Med Chem 38:3053-61 (1995) [PubMed]  Article 
Target
Name:
Deoxyhypusine synthase
Synonyms:
DHYS_RAT | Dhps
Type:
PROTEIN
Mol. Mass.:
40696.63
Organism:
Rattus norvegicus
Description:
ChEMBL_53735
Residue:
369
Sequence:
MEGTPSGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAYGTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHEDLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVQEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED
  
Inhibitor
Name:
BDBM50032502
Synonyms:
CHEMBL103266 | N-[6-(6-Amino-hexylamino)-hexyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C13H31N5
Mol. Mass.:
257.4187
SMILES:
NCCCCCCNCCCCCCNC(N)=N
Structure:
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