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Target
Ecdysone receptor/Ultraspiracle
Ligand
BDBM50226672
Substrate
n/a
Meas. Tech.
ChEMBL_927055 (CHEMBL3073226)
IC50
1380±n/a nM
Citation
 Tohidi-Esfahani, D; Lawrence, MC; Graham, LD; Hannan, GN; Simpson, AM; Hill, RJ Isoforms of the heteropteran Nezara viridula ecdysone receptor: protein characterisation, RH5992 insecticide binding and homology modelling. Pest Manag Sci 67:1457-67 (2011) [PubMed]  Article 
Target
Name:
Ecdysone receptor/Ultraspiracle
Synonyms:
Ecdysone receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 927055
Components:
This complex has 2 components.
Component 1
Name:
Ecdysone receptor
Synonyms:
Ecdysone receptor isoform A
Type:
PROTEIN
Mol. Mass.:
50654.25
Organism:
Nezara viridula
Description:
ChEMBL_106733
Residue:
444
Sequence:
MCEESRRDEWTVGGGQNGCPSPTMSSNSYEPYSPASKLGREDLSPANSLNGFSADSCDGSKKKKGSAARQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYQCKYGNNCEIDMYMRRKCQECRLKKCLSVGMRPECVVPEYQCAVKRKEKKAQKDKDKPVSTTNGSPESIKVEEPHRVVYKTEGETLGRPVPINGVKPVSPEQEELIHRLVYFQNEYEHPSEEDLRRIVSNTPNEDEEQSDQRFRHLTEITILTVQLIVEFAKRLPGFDKLLREDQIALLKACSSEVMMLRMARKYDATTDSILFANNQPYNRESYSLAGMGDVIEDLLRFCRHMFNMKVDNAEYALLTAIVIFSERPALIEGWKVEKIQEIYLEALKSYVDNRSRPRSPTIFAKLLSVLTELRTLGNQNSEMCFSLKLQNKKLPPFLAEIWDVNT
  
Component 2
Name:
Ultraspiracle
Synonyms:
USP | Ultraspiracle
Type:
PROTEIN
Mol. Mass.:
45382.50
Organism:
Nezara viridula
Description:
ChEMBL_106733
Residue:
402
Sequence:
MEANERGLSLENNLSLVGPQSPLDMKPDAASLLAGSFSPSQASNPTSPAGFGMAHNSVLGNGNKSLNTPYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREDKQCLVDKRQRNRCQYCRYQKCLSMGMKREAVQEERQRTKERDQNEVESTSSFHTDMPVERILEAERRVDFKVEPMVEYENANTLFQATDKQLVQLVEWAKQIPHFTSLPIEDQVLLLRAGWNELLIAGFSHRSIGVKEKIVLGSGVTVCRNTAHQAGVDTIFDRALTELVSKMREMKMDKAELGCLRTIILYNPEVRGLRSVGEVEALREKVYASLEEYTRSTHPEEPGRFAKLLLRLPSLRSIGLKCLEPLFFYRVLHDIPIDTFLLQMLESSDLSNRL
  
Inhibitor
Name:
BDBM50226672
Synonyms:
CHEMBL255034 | makisterone A
Type:
Small organic molecule
Emp. Form.:
C28H46O7
Mol. Mass.:
494.6606
SMILES:
C[C@H](C[C@@H](O)[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C)C(C)(C)O |t:13|
Structure:
Search PDB for entries with ligand similarity: