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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50122395
Substrate
n/a
Meas. Tech.
ChEMBL_932679 (CHEMBL3070436)
IC50
0.500035±n/a nM
Citation
  TBA Med Chem Res 22:1773-1787 (2013)    Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50122395
Synonyms:
5-(2-Chloro-4-fluoro-phenyl)-7-(1-cyclopropylmethyl-piperidin-4-yl)-1-(2,6-dichloro-phenyl)-3,4-dihydro-1H-quinazolin-2-one | 5-(2-chloro-4-fluorophenyl)-7-(1-(cyclopropylmethyl)piperidin-4-yl)-1-(2,6-dichlorophenyl)-3,4-dihydroquinazolin-2(1H)-one | CHEMBL419134
Type:
Small organic molecule
Emp. Form.:
C29H27Cl3FN3O
Mol. Mass.:
558.902
SMILES:
Fc1ccc(c(Cl)c1)-c1cc(cc2N(C(=O)NCc12)c1c(Cl)cccc1Cl)C1CCN(CC2CC2)CC1
Structure:
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