Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50034381
Substrate
n/a
Meas. Tech.
ChEMBL_31070
Ki
2920±n/a nM
Citation
 Catarzi, D; Cecchi, L; Colotta, V; Filacchioni, G; Martini, C; Tacchi, P; Lucacchini, A Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines. J Med Chem 38:1330-6 (1995) [PubMed]  Article  BDB Entry
Target
Name:
Adenosine receptor A2a
Synonyms:
ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50034381
Synonyms:
6-Bromo-3-methyl-1-phenyl-1H-chromeno[2,3-c]pyrazol-4-one | CHEMBL27773
Type:
Small organic molecule
Emp. Form.:
C17H11BrN2O2
Mol. Mass.:
355.185
SMILES:
Cc1nn(-c2ccccc2)c2oc3ccc(Br)cc3c(=O)c12
Structure:
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