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Target
Endothelin-1 receptor
Ligand
BDBM50034460
Substrate
n/a
Meas. Tech.
ChEMBL_63217 (CHEMBL674069)
IC50
2890±n/a nM
Citation
 Stein, PD; Floyd, DM; Bisaha, S; Dickey, J; Girotra, RN; Gougoutas, JZ; Kozlowski, M; Lee, VG; Liu, EC; Malley, MF Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists. J Med Chem 38:1344-54 (1995) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50034460
Synonyms:
5-(1-Hydroxy-1-methyl-ethyl)-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | CHEMBL431300
Type:
Small organic molecule
Emp. Form.:
C18H20N2O4S
Mol. Mass.:
360.427
SMILES:
Cc1noc(NS(=O)(=O)c2cccc3c(cccc23)C(C)(C)O)c1C
Structure:
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