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Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM50035204
Substrate
n/a
Meas. Tech.
ChEMBL_177000 (CHEMBL779290)
IC50
10000±n/a nM
Citation
 Hartmann, RW; Bayer, H; Grün, G; Sergejew, T; Bartz, U; Mitrenga, M Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom. J Med Chem 38:2103-11 (1995) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase
Type:
PROTEIN
Mol. Mass.:
58260.64
Organism:
Rattus norvegicus
Description:
ChEMBL_224979
Residue:
510
Sequence:
MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
  
Inhibitor
Name:
BDBM50035204
Synonyms:
4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-pyridine | 4-(6-methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)pyridine | CHEMBL294361
Type:
Small organic molecule
Emp. Form.:
C17H17NO
Mol. Mass.:
251.323
SMILES:
COc1ccc2CCC3C(C3c2c1)c1ccncc1
Structure:
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