Reaction Details Report a problem with these data
Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM50378780
Substrate
n/a
Meas. Tech.
ChEMBL_177001 (CHEMBL779291)
IC50
12000±n/a nM
Citation
 Hartmann, RW; Bayer, H; Grün, G; Sergejew, T; Bartz, U; Mitrenga, M Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom. J Med Chem 38:2103-11 (1995) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase
Type:
PROTEIN
Mol. Mass.:
58260.64
Organism:
Rattus norvegicus
Description:
ChEMBL_224979
Residue:
510
Sequence:
MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
  
Inhibitor
Name:
BDBM50378780
Synonyms:
(S)-VOROZOLE
Type:
Small organic molecule
Emp. Form.:
C16H13ClN6
Mol. Mass.:
324.768
SMILES:
Cn1nnc2ccc(cc12)[C@H](c1ccc(Cl)cc1)n1cncn1 |r|
Structure:
Search PDB for entries with ligand similarity: