Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50490794
Substrate
n/a
Meas. Tech.
ChEMBL_953006 (CHEMBL2352544)
IC50
3980±n/a nM
Citation
 Hamidian, H; Tagizadeh, R; Fozooni, S; Abbasalipour, V; Taheri, A; Namjou, M Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors. Bioorg Med Chem 21:2088-92 (2013) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50490794
Synonyms:
CHEMBL2348686
Type:
Small organic molecule
Emp. Form.:
C29H18F3N3O5
Mol. Mass.:
545.4655
SMILES:
CC(=O)Oc1c(ccc2ccccc12)\N=N\c1ccc(cc1)C1=N\C(=C\c2ccc(OC(F)(F)F)cc2)C(=O)O1 |t:25|
Structure:
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