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Target
Neutrophil elastase
Ligand
BDBM50035530
Substrate
n/a
Meas. Tech.
ChEMBL_63961 (CHEMBL677430)
Ki
25±n/a nM
Citation
 Burkhart, JP; Koehl, JR; Mehdi, S; Durham, SL; Janusz, MJ; Huber, EW; Angelastro, MR; Sunder, S; Metz, WA; Shum, PW Inhibition of human neutrophil elastase. 3. An orally active enol acetate prodrug. J Med Chem 38:223-33 (1995) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50035530
Synonyms:
CHEMBL74651 | Propionic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2-[4-(morpholine-4-carbonyl)-benzoylamino]-butyryl}-pyrrolidine-2-carbonyl)-amino]-1-pentafluoroethyl-but-1-enyl ester
Type:
Small organic molecule
Emp. Form.:
C32H41F5N4O7
Mol. Mass.:
688.6826
SMILES:
CCC(=O)O\C(=C(\NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(cc1)C(=O)N1CCOCC1)C(C)C)C(C)C)C(F)(F)C(F)(F)F
Structure:
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