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Target
Cathepsin B
Ligand
BDBM50213272
Substrate
n/a
Meas. Tech.
ChEMBL_961531 (CHEMBL2388562)
Ki
5.0±n/a nM
Citation
 Dana, D; Davalos, AR; De, S; Rathod, P; Gamage, RK; Huestis, J; Afzal, N; Zavlanov, Y; Paroly, SS; Rotenberg, SA; Subramaniam, G; Mark, KJ; Chang, EJ; Kumar, S Development of cell-active non-peptidyl inhibitors of cysteine cathepsins. Bioorg Med Chem 21:2975-87 (2013) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50213272
Synonyms:
CHEBI:6426 | Leupeptin
Type:
Small organic molecule
Emp. Form.:
C20H38N6O4
Mol. Mass.:
426.5535
SMILES:
CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O |r|
Structure:
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