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Target
Chymotrypsin-like elastase family member 2A
Ligand
BDBM50036127
Substrate
n/a
Meas. Tech.
ChEMBL_156955 (CHEMBL762665)
Ki
4600±n/a nM
Citation
 Damewood, JR; Edwards, PD; Feeney, S; Gomes, BC; Steelman, GB; Tuthill, PA; Williams, JC; Warner, P; Woolson, SA; Wolanin, DJ Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones. J Med Chem 37:3303-12 (1994) [PubMed]  Article 
Target
Name:
Chymotrypsin-like elastase family member 2A
Synonyms:
CEL2A_PIG | CELA2A | ELA2 | ELA2A | Elastase 2A | Elastase-2 | Elastase-2A | Pancreatic elastase
Type:
PROTEIN
Mol. Mass.:
28705.23
Organism:
Sus scrofa
Description:
ChEMBL_156951
Residue:
269
Sequence:
MIRALLLSTLVAGALSCGLPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGGTLVDQSWVLTAAHCISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGNDIALLKLASPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQLLVVDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQWQVHGIVSFGSSLGCNYYHKPSVFTRVSNYIDWINSVIANN
  
Inhibitor
Name:
BDBM50036127
Synonyms:
CHEMBL11391 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C27H26F3N3O5
Mol. Mass.:
529.5076
SMILES:
CC(C)C(NC(=O)Cn1c(ccc(NC(=O)OCc2ccccc2)c1=O)-c1ccccc1)C(=O)C(F)(F)F
Structure:
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