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Target
Acetylcholinesterase
Ligand
BDBM50041234
Substrate
n/a
Meas. Tech.
ChEMBL_972045 (CHEMBL2406149)
IC50
760±n/a nM
Citation
 Ben Salem, S; Jabrane, A; Harzallah-Skhiri, F; Ben Jannet, H New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire. Bioorg Med Chem Lett 23:4248-52 (2013) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM50041234
Synonyms:
6-hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone | 8-MP | 8-methoxy-2',3',6,7-furocoumarin | 8-methoxy-4',5':6,7-furocoumarin | 8-methoxy-[furano-3'.2':6.7-coumarin] | 8-methoxypsoralen | 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one | 9-methoxy-7H-furo[3,2-g]chromen-7-one | CHEMBL416 | METHOXSALEN | xanthotoxin
Type:
Small organic molecule
Emp. Form.:
C12H8O4
Mol. Mass.:
216.1895
SMILES:
COc1c2occc2cc2ccc(=O)oc12
Structure:
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