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Target
Integrase
Ligand
BDBM50492505
Substrate
n/a
Meas. Tech.
ChEMBL_972307 (CHEMBL2411983)
IC50
35±n/a nM
Citation
 Billamboz, M; Suchaud, V; Bailly, F; Lion, C; Demeulemeester, J; Calmels, C; Andréola, ML; Christ, F; Debyser, Z; Cotelle, P 4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors. ACS Med Chem Lett 4:606-11 (2013) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50492505
Synonyms:
CHEMBL2407283
Type:
Small organic molecule
Emp. Form.:
C19H18N2O6
Mol. Mass.:
370.356
SMILES:
COc1ccc(CNC(=O)C2C(=O)N(O)C(=O)c3ccccc23)c(OC)c1
Structure:
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