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Target
Delta-type opioid receptor
Ligand
BDBM50492549
Substrate
n/a
Meas. Tech.
ChEMBL_972710 (CHEMBL2410919)
Ki
2798±n/a nM
Citation
 Lesma, G; Salvadori, S; Airaghi, F; Murray, TF; Recca, T; Sacchetti, A; Balboni, G; Silvani, A Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics. ACS Med Chem Lett 4:795-9 (2013) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50492549
Synonyms:
CHEMBL2409171
Type:
Small organic molecule
Emp. Form.:
C36H42F3N5O7
Mol. Mass.:
713.7432
SMILES:
OC(=O)C(F)(F)F.N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: