Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50318633
Substrate
n/a
Meas. Tech.
ChEMBL_975659 (CHEMBL2416143)
Ki
0.230000±n/a nM
Citation
 Ivachtchenko, A; Golovina, E; Kadieva, M; Mitkin, O; Tkachenko, S; Okun, I Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-??6 receptors. Bioorg Med Chem 21:4614-27 (2013) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50318633
Synonyms:
3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEMBL1083390 | SB-742457
Type:
Small organic molecule
Emp. Form.:
C19H19N3O2S
Mol. Mass.:
353.438
SMILES:
O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: