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Target
Dihydrofolate reductase
Ligand
BDBM50038269
Substrate
n/a
Meas. Tech.
ChEMBL_53622 (CHEMBL663691)
pH
6.6±n/a
Kd
1600±n/a nM
Comments
extracted
Citation
 Ivery, MT; Gready, JE Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase. J Med Chem 37:4211-21 (1995) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50038269
Synonyms:
2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one | CHEMBL135937
Type:
Small organic molecule
Emp. Form.:
C12H18N4O
Mol. Mass.:
234.2975
SMILES:
CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15|
Structure:
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