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Target
Sterol O-acyltransferase 1
Ligand
BDBM50028877
Substrate
n/a
Meas. Tech.
ChEMBL_28495 (CHEMBL645925)
IC50
7500±n/a nM
Citation
 Burnett, DA; Caplen, MA; Davis, HR; Burrier, RE; Clader, JW 2-Azetidinones as inhibitors of cholesterol absorption. J Med Chem 37:1733-6 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50028877
Synonyms:
(3S,4R)-1-(4-Methoxy-phenyl)-3,4-diphenyl-3-phenylacetyl-azetidin-2-one | CHEMBL49273
Type:
Small organic molecule
Emp. Form.:
C30H25NO3
Mol. Mass.:
447.5244
SMILES:
COc1ccc(cc1)N1[C@H](c2ccccc2)[C@@](C(=O)Cc2ccccc2)(C1=O)c1ccccc1
Structure:
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