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Target
Sterol O-acyltransferase 1
Ligand
BDBM50005944
Substrate
n/a
Meas. Tech.
ChEMBL_28495 (CHEMBL645925)
IC50
6000±n/a nM
Citation
 Burnett, DA; Caplen, MA; Davis, HR; Burrier, RE; Clader, JW 2-Azetidinones as inhibitors of cholesterol absorption. J Med Chem 37:1733-6 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50005944
Synonyms:
2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide | CHEMBL22373 | CI-976
Type:
Small organic molecule
Emp. Form.:
C23H39NO4
Mol. Mass.:
393.5601
SMILES:
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
Structure:
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