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Target
Sterol O-acyltransferase 1
Ligand
BDBM50028880
Substrate
n/a
Meas. Tech.
ChEMBL_28495 (CHEMBL645925)
IC50
1700±n/a nM
Citation
 Burnett, DA; Caplen, MA; Davis, HR; Burrier, RE; Clader, JW 2-Azetidinones as inhibitors of cholesterol absorption. J Med Chem 37:1733-6 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50028880
Synonyms:
(3S,4R)-3-Ethyl-4-phenyl-3-(3-phenyl-propyl)-1-(2,4,6-trimethoxy-phenyl)-azetidin-2-one | CHEMBL47509
Type:
Small organic molecule
Emp. Form.:
C29H33NO4
Mol. Mass.:
459.5766
SMILES:
CC[C@]1(CCCc2ccccc2)[C@H](N(C1=O)c1c(OC)cc(OC)cc1OC)c1ccccc1
Structure:
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