Reaction Details Report a problem with these data
Target
Beta-1 adrenergic receptor
Ligand
BDBM50040068
Substrate
n/a
Meas. Tech.
ChEBML_216051
Ki
160±n/a nM
Citation
 Cecchetti, V; Fravolini, A; Schiaffella, F; Tabarrini, O; Bruni, G; Segre, G o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents. J Med Chem 36:157-61 (1993) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50040068
Synonyms:
4-Chloro-benzene-1,3-disulfonic acid 3-amide 1-({2-[2-hydroxy-3-(naphthalen-1-yloxy)-propylamino]-ethyl}-amide) | CHEMBL43196
Type:
Small organic molecule
Emp. Form.:
C21H24ClN3O6S2
Mol. Mass.:
514.015
SMILES:
NS(=O)(=O)c1cc(ccc1Cl)S(=O)(=O)NCCNCC(O)COc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: