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Target
Tubulin beta-2B chain
Ligand
BDBM50041109
Substrate
n/a
Meas. Tech.
ChEMBL_211333 (CHEMBL820776)
IC50
1300±n/a nM
Citation
 Li, L; Wang, HK; Kuo, SC; Wu, TS; Lednicer, D; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 37:1126-35 (1994) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50041109
Synonyms:
6-(1H-Indol-3-yl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | CHEMBL273990
Type:
Small organic molecule
Emp. Form.:
C18H12N2O3
Mol. Mass.:
304.2995
SMILES:
Oc1cc(nc2cc3OCOc3cc12)-c1c[nH]c2ccccc12
Structure:
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